these reactions may occur following the first dose or multiple doses levaquin indication. levofloxacin also penetrates into lung tissues. 4 to 11. the peak and trough plasma concentrations attained following multiple once-daily oral 500 mg regimens were approximately 5. the blister fluid to plasma auc ratio is approximately 1 levaquin iv. therefore, microorganisms resistant to these latter classes of antimicrobial agents may be susceptible to fluoroquinolones. treatment for some infections may take 6 weeks or longer. levofloxacin undergoes limited metabolism in humans and is primarily excreted as unchanged drug (87%) in the urine within 48 hours. for example, b-lactamase production and alterations in penicillin-binding proteins have no effect on levofloxacin activity. : following a single 60-minute i. it works by eliminating bacteria that cause infections. appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing the infection and to determine their susceptibility to levofloxacin antibiotic levaquin. the absolute bioavailability of a 500 mg oral dose of levofloxacin is approximately 99% information on levaquin. levofloxacin is the l-isomer of the racemate, ofloxacin, a quinolone antibacterial agent. take gonorrhea levaquin with a full glass of water (8 ounces). the most frequently reported side events are nausea or vomiting (1 out of every 12 persons), diarrhea (1 out 20), headache (1 out 20), and constipation (1 out of 30). bacterial infection: the pharmacokinetics of levofloxacin in patients with community-acquired bacterial infections are comparable to those observed in healthy subjects dose levaquin. gender: there are no significant differences in levofloxacin pharmacokinetics between male and female subjects when the differences in creatinine clearance are taken into consideration. do not give this medicine to a child younger than 18 years old. levofloxacin is used treat infections such as pneumonia; chronic bronchitis; and sinus, urinary tract, kidney, and skin infections. i levaquin used for. , creatinine clearance > 80 ml/min). the antibacterial activity of ofloxacin resides primarily in the l-isomer. levofloxacin is 24 to 38% bound to serum proteins across all species studied. for patients with altered renal function see the patients with impaired renal function subsection. tablets should be taken with a full glass of water levaquin levofloxacin. levofloxacin is not recommended for use in pregnant women since levofloxacin causes joint and bone deformities in juvenile animals of several species. levofloxacin is used to treat infections of the sinuses, skin, lungs, ears, airways, bones, and joints caused by susceptible bacteria. these recommendations apply to patients with normal renal function (i antibiotic levaquin. antibiotics will not work for colds, flu, or other viral infections.